If it’s downloaded onto your machine, it can be blocked. It’s impossible to prevent a dedicated enough community from blocking ads. YouTube hasn’t even been able to keep users from doing it; they’ve had to resort to changing their platform (Chrome) to make it harder, but that just means people have to use other platforms.

It’s your machine, and you have admin rights on it. That means you control the data and display of that machine; ad block blocking is Quixotic at best, and neurotic at worst. Which YouTube has discovered.